Clinical trials for Penile cancer and germ cell tumors

Phase 1 Breast cancer Lung cancer Prostate cancer Colon cancer Rectal cancer Anal cancer Kidney cancer Pancreas cancer Liver and bile duct cancer Bladder / Urinary Tract / Urethral cancer Stomach and esophageal cancer Endometrial cancer Ovarian / Fallopian tubes / Peritoneum cancer Head and neck cancer Sarcoma and GIST Thymus cancer Penile cancer and germ cell tumors Cervical / Vulvar / Vaginal cancer Small intestine and appendix cancer #NCT06026410

KO-2806 Monothérapie et thérapies combinées dans les tumeurs solides avancées

Bras 1 (Tumeurs solides avancées avec altération du gène RAS)

Locally Advanced Metastatic Other KRAS HRAS KRAS G12C KRAS G12D KRAS non G12C NRAS 1 2 3 or more

Systemic Treatment-Naive

3 recruiting sites

Kura Oncologie, Inc.

Phase 1 Breast cancer Lung cancer Prostate cancer Colon cancer Rectal cancer Anal cancer Kidney cancer Pancreas cancer Liver and bile duct cancer Bladder / Urinary Tract / Urethral cancer Stomach and esophageal cancer Endometrial cancer Ovarian / Fallopian tubes / Peritoneum cancer Head and neck cancer Sarcoma and GIST Thymus cancer Penile cancer and germ cell tumors Cervical / Vulvar / Vaginal cancer Small intestine and appendix cancer #NCT06179160 #2023-507091-47-00

Étude visant à évaluer l'INCB161734 chez des participants atteints de tumeurs solides avancées ou métastatiques présentant une mutation KRAS G12D

Locally Advanced Metastatic KRAS G12D 1 2 3 or more

Systemic Treatment-Naive

3 recruiting sites

Incyte Corporation

Phase 1 Breast cancer Lung cancer Prostate cancer Colon cancer Rectal cancer Anal cancer Kidney cancer Pancreas cancer Liver and bile duct cancer Bladder / Urinary Tract / Urethral cancer Stomach and esophageal cancer Endometrial cancer Ovarian / Fallopian tubes / Peritoneum cancer Head and neck cancer Sarcoma and GIST Thymus cancer Penile cancer and germ cell tumors Cervical / Vulvar / Vaginal cancer Small intestine and appendix cancer #NCT07094113

AMG 410 seul et en association avec d'autres agents chez des participants atteints de tumeurs solides avancées ou métastatiques présentant une altération du gène KRAS

Parties 1, 2 et 3a

Locally Advanced Metastatic Other KRAS KRAS G12C KRAS G12D KRAS non G12C 1 2 3 or more

Systemic Treatment-Naive

2 recruiting sites

Amgen

Phase 1 Lung cancer Liver and bile duct cancer Stomach and esophageal cancer Penile cancer and germ cell tumors #NCT06427941 #2025-524136-19-00

Étude de phase 1 du BGB-B2033, seul ou en association avec le tislelizumab, avec ou sans bevacizumab, chez des participants atteints de tumeurs solides avancées ou métastatiques

Parties A et B

NSCLC (Non-Small Cell Lung Cancer) Stomach Germ cell tumor Hepatocellular carcinoma Non-seminomatous tumor Locally Advanced Metastatic Unhealthy B C 1 2 3 or more

Systemic Treatment-Naive

3 recruiting sites

BeOne Medecines

Phase 1 Endometrial cancer Ovarian / Fallopian tubes / Peritoneum cancer Penile cancer and germ cell tumors #NCT07306559

Une étude visant à tester la tolérance de différentes doses de BI 3820768 chez les personnes atteintes d'un cancer avancé (tumeurs solides)

Germ cell tumor Metastatic 1 2 3 or more

Systemic Treatment-Naive

1 recruiting site

Boehringer Ingelheim

Phase 1 Breast cancer Lung cancer Prostate cancer Colon cancer Rectal cancer Kidney cancer Pancreas cancer Liver and bile duct cancer Bladder / Urinary Tract / Urethral cancer Stomach and esophageal cancer Endometrial cancer Ovarian / Fallopian tubes / Peritoneum cancer Head and neck cancer Sarcoma and GIST Thymus cancer Penile cancer and germ cell tumors Cervical / Vulvar / Vaginal cancer #NCT06619587

Étude visant à évaluer la sécurité, la pharmacocinétique et l'activité du GDC-7035 en monothérapie et en association chez des patients atteints de tumeurs solides avancées