Clinical trials for Sarcoma and GIST

86 currently recruiting clinical trials
Phase 1 / Phase 2 Breast cancer Lung cancer Prostate cancer Colon cancer Rectal cancer Anal cancer Kidney cancer Pancreas cancer Liver and bile duct cancer Bladder / Urinary Tract / Urethral cancer Stomach and esophageal cancer Endometrial cancer Ovarian / Fallopian tubes / Peritoneum cancer Head and neck cancer Sarcoma and GIST Thymus cancer Penile cancer and germ cell tumors Cervical / Vulvar / Vaginal cancer Small intestine and appendix cancer #NCT06128551
Phase 1b Escalade de dose
Required disease stage
Locally Advanced Metastatic Metastatic Castration-resistant
Required genetic anomalies
KRAS G12C
Required number of previous lines of therapy for current stage of disease
1 2 3 or more
Excluded previous treatments at advanced or metastatic stage
Systemic Treatment-Naive
7 recruiting sites
Revolution Medicines, Inc.
Phase 1 / Phase 2 Prostate cancer Colon cancer Rectal cancer Anal cancer Kidney cancer Pancreas cancer Liver and bile duct cancer Bladder / Urinary Tract / Urethral cancer Stomach and esophageal cancer Head and neck cancer Sarcoma and GIST Thymus cancer Penile cancer and germ cell tumors Cervical / Vulvar / Vaginal cancer Small intestine and appendix cancer #NCT04585750 #2023-504251-27-00
Phase 2 autres tumeurs solides
Required disease stage
Locally Advanced Metastatic Metastatic Castration-resistant
Required genetic anomalies
TP53
Required number of previous lines of therapy for current stage of disease
1 2 3 or more
Excluded genetic anomalies
KRAS G12C KRAS non G12C
Excluded previous treatments at advanced or metastatic stage
Systemic Treatment-Naive
9 recruiting sites
PMV Pharmaceuticals, Inc
Phase 1 / Phase 2 Breast cancer Lung cancer Prostate cancer Colon cancer Rectal cancer Anal cancer Kidney cancer Pancreas cancer Liver and bile duct cancer Bladder / Urinary Tract / Urethral cancer Stomach and esophageal cancer Endometrial cancer Ovarian / Fallopian tubes / Peritoneum cancer Head and neck cancer Sarcoma and GIST Thymus cancer Penile cancer and germ cell tumors Cervical / Vulvar / Vaginal cancer #NCT07213817 #2025-522139-33-00
Required disease stage
Locally Advanced Metastatic Metastatic Castration-resistant
Required number of previous lines of therapy for current stage of disease
1
Excluded previous treatments at advanced or metastatic stage
Systemic Treatment-Naive
3 recruiting sites
Ipsen
Phase 1 / Phase 2 Breast cancer Stomach and esophageal cancer Sarcoma and GIST Cervical / Vulvar / Vaginal cancer #NCT06795412 #2025-521828-30-00
Partie 1 Autres tumeurs solides
Required histologic types
Stomach Oesogastric junction Bone sarcoma Soft tissue sarcoma Cervical cancer
Required histologic sub types
Adenocarcinoma Osteosarcoma Chordoma Squamous cell carcinoma Adenosquamous carcinoma
Required HER2 statuses
HER2 Negative
Required HR statuses
HR Negative HR Positive
Required disease stage
Locally Advanced Metastatic
4 recruiting sites
Pyxis Oncology, Inc
Phase 1 / Phase 2 Stomach and esophageal cancer Sarcoma and GIST #NCT05957367 #2024-516476-15-00
Module B Partie 2
Required histologic types
GIST
Required histologic sub types
Gastrointestinal stromal tumor
Required disease stage
Locally Advanced Metastatic
Required genetic anomalies
KIT
Required number of previous lines of therapy for current stage of disease
1
Required previous treatments at advanced or metastatic stage
Targeted therapy
Excluded previous treatments at advanced or metastatic stage
Systemic Treatment-Naive
3 recruiting sites
Deciphera Pharmaceuticals, LLC
Phase 1 / Phase 2 Stomach and esophageal cancer Sarcoma and GIST #NCT05957367 #2024-516476-15-00
Module B Partie 1
Required histologic types
GIST
Required histologic sub types
Gastrointestinal stromal tumor
Required disease stage
Locally Advanced Metastatic
Required genetic anomalies
KIT PDGFRA
Required number of previous lines of therapy for current stage of disease
1 2 3 or more
Excluded previous treatments at advanced or metastatic stage
Systemic Treatment-Naive
2 recruiting sites
Deciphera Pharmaceuticals, LLC
Phase 1 / Phase 2 Breast cancer Prostate cancer Colon cancer Rectal cancer Anal cancer Kidney cancer Pancreas cancer Liver and bile duct cancer Bladder / Urinary Tract / Urethral cancer Stomach and esophageal cancer Endometrial cancer Ovarian / Fallopian tubes / Peritoneum cancer Head and neck cancer Sarcoma and GIST Thymus cancer Penile cancer and germ cell tumors #NCT05118789
Required disease stage
Locally Advanced Metastatic
Required genetic anomalies
ROS-1
Required number of previous lines of therapy for current stage of disease
1
4 recruiting sites
Nuvalent Inc.
Phase 1 / Phase 2 Sarcoma and GIST #NCT02275286 #2024-518199-30-00
Cohorte D
Required histologic types
Soft tissue sarcoma
Required disease stage
Localized
Required number of previous lines of therapy for current stage of disease
None 1
Required previous treatments at localized stage
Systemic Treatment-Naive Chemotherapy
Required soft tissue sarcoma locations
Retroperitoneum
Required sarcoma grades
Grade 2
Excluded previous treatments at localized stage
Surgery Radiotherapy
2 recruiting sites
Grupo Espanol de Investigacion en Sarcomas
Phase 1 / Phase 2 Sarcoma and GIST #NCT02275286 #2024-518199-30-00
Cohorte C
Required histologic types
Soft tissue sarcoma
Required disease stage
Localized
Required number of previous lines of therapy for current stage of disease
None
Required previous treatments at localized stage
Systemic Treatment-Naive
Required soft tissue sarcoma locations
Retroperitoneum
Required sarcoma grades
Grade 2 Grade 3
Excluded previous treatments at localized stage
Surgery Chemotherapy Radiotherapy
2 recruiting sites
Grupo Espanol de Investigacion en Sarcomas
Phase 1 / Phase 2 Sarcoma and GIST #NCT02275286 #2024-518199-30-00
Cohorte D
Required histologic types
Soft tissue sarcoma
Required disease stage
Localized
Required number of previous lines of therapy for current stage of disease
None 1
Required previous treatments at localized stage
Systemic Treatment-Naive Chemotherapy
Required soft tissue sarcoma locations
Retroperitoneum
2 recruiting sites
Grupo Espanol de Investigacion en Sarcomas