Cancer clinical trials in the region Centre-Val de Loire
112 currently recruiting clinical trials
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Phase 2
Myelodysplastic Syndromes (MDS) and Myeloproliferative Neoplasms (MPN)
#NCT05980806
#2024-511309-47-00
Required histologic types
Myeloproliferative neoplasms (MPN)
Required histologic sub types
Primary myelofibrosis
Secondary myelofibrosis
Required DIPSS scores
Intermediate-1
Intermediate-2
High
Excluded previous treatments
Targeted therapy
8 recruiting sites
Karyopharm Therapeutics Inc.
Phase 2
Breast cancer
#NCT05973864
#2023-505291-30-01
Required HER2 statuses
HER2 Negative
Required HR statuses
HR Negative
Required disease stage
Localized
Required number of previous lines of therapy for current stage of disease
None
Required previous treatments at localized stage
Systemic Treatment-Naive
Excluded previous treatments at localized stage
Surgery
Immunotherapy
Chemotherapy
20 recruiting sites
UNICANCER
Phase 2
Stomach and esophageal cancer
Sarcoma and GIST
#NCT05152472
#2022-503068-34-00
Required histologic types
GIST
Required histologic sub types
Gastrointestinal stromal tumor
Required disease stage
Locally Advanced
Metastatic
Required number of previous lines of therapy for current stage of disease
3 or more
Required previous treatments at advanced or metastatic stage
Targeted therapy
Excluded previous treatments at advanced or metastatic stage
Systemic Treatment-Naive
Immunotherapy
11 recruiting sites
Centre Léon Bérard
Phase 2
Liver and bile duct cancer
#NCT06254248
#2024-514400-14-00
Required histologic sub types
Hepatocellular carcinoma
Required disease stage
Locally Advanced
Metastatic
Required liver status
Unhealthy
Required Child-Pugh scores
A
Required number of previous lines of therapy for current stage of disease
None
Required previous treatments at localized stage
Transplant
Required previous treatments at advanced or metastatic stage
Systemic Treatment-Naive
10 recruiting sites
Assistance Publique - Hôpitaux de Paris
Phase 2
Breast cancer
#NCT06680596
#2024-515349-41-00
Required HER2 statuses
HER2 Low
Required HR statuses
HR Positive
Required disease stage
Metastatic
Required number of previous lines of therapy for current stage of disease
None
Excluded previous treatments at advanced or metastatic stage
Antibody Drug Conjugates (ADC)
Hormone therapy
34 recruiting sites
UNICANCER
Phase 2
Acute leukemia
#NCT05260528
#2022-500295-60-00
Required histologic types
Acute myeloid leukemia (AML)
Required number of previous lines of therapy
None
31 recruiting sites
Centre Hospitalier Universitaire de Nice
Phase 2
Liver and bile duct cancer
#NCT07036380
#2024-520029-35-00
Required histologic sub types
Intrahepatic cholangiocarcinoma
Extrahepatic cholangiocarcinoma
Required disease stage
Locally Advanced
Metastatic
Required number of previous lines of therapy for current stage of disease
None
Required previous treatments at advanced or metastatic stage
Systemic Treatment-Naive
Excluded previous treatments at advanced or metastatic stage
Immunotherapy
9 recruiting sites
Centre Hospitalier Universitaire de Besancon
Phase 2
Breast cancer
#NCT04985266
Phase de surveillance de l’ADN tumoral circulant
Required HER2 statuses
HER2 Negative
Required HR statuses
HR Positive
Required disease stage
Localized
Required number of previous lines of therapy for current stage of disease
None
Required previous treatments at localized stage
Surgery
Chemotherapy
Hormone therapy
Excluded previous treatments at localized stage
Targeted therapy
18 recruiting sites
Fiducie de la Fondation Royal Marsden NHS
Phase 2
Lymphoma
#NCT06806033
#2024-516791-15-00
Required histologic types
B cell lymphoma
Required histologic sub types
Large B cell lymphoma
Indolent transformed lymphoma
Required central nervous system lesions
None
Treated / Controled
Required number of previous lines of therapy
1
2
3 or more
Excluded previous treatments
Systemic Treatment-Naive
Bispecific T-cell engager antibodies
Allogeneic stem cell transplant
4 recruiting sites
Hoffmann-La Roche
Phase 2
Colon cancer
Rectal cancer
#NCT04262687
Required disease stage
Metastatic
Required genetic anomalies
MSS/pMMR
Required number of previous lines of therapy for current stage of disease
None
1
Required previous treatments at advanced or metastatic stage
Systemic Treatment-Naive
Surgery
Chemotherapy
Excluded genetic anomalies
MSI/dMMR
Excluded previous treatments at localized stage
Immunotherapy
Excluded previous treatments at advanced or metastatic stage
Immunotherapy
62 recruiting sites
Fédération Francophone de Cancérologie Digestive