Clinical trials for Chronic myeloid leukemia (CML)

24 currently recruiting clinical trials

Phase 3 Chronic myeloid leukemia (CML) #NCT06423911
Required disease stage
Chronic phase
Required genetic anomalies
T315I
1 recruiting site
Ascentage Pharma Group Inc.
Phase 3 Chronic myeloid leukemia (CML) #NCT06423911
Required disease stage
Chronic phase
Required number of previous lines of therapy
2 3 or more
Required previous treatments
ATP pocket inhibitor Allosteric inhibitor
Excluded genetic anomalies
T315I
Excluded previous treatments
Systemic Treatment-Naive
1 recruiting site
Ascentage Pharma Group Inc.
Phase 2 Chronic myeloid leukemia (CML) #NCT02889003
Required number of previous lines of therapy
1
Required previous treatments
ATP pocket inhibitor Allosteric inhibitor
Excluded genetic anomalies
BCR-ABL
Excluded previous treatments
Systemic Treatment-Naive Allogeneic stem cell transplant
3 recruiting sites
Hôpital de Versailles
Phase 2 Chronic myeloid leukemia (CML) #NCT06514534 #2024-516049-38-00
Required disease stage
Chronic phase Accelerated phase
Required genetic anomalies
T315I
Required number of previous lines of therapy
1 2 3 or more
Required previous treatments
ATP pocket inhibitor
Excluded previous treatments
Systemic Treatment-Naive Allosteric inhibitor
7 recruiting sites
Novartis
Phase 1 / Phase 2 Chronic myeloid leukemia (CML) #NCT04835584
Required disease stage
Accelerated phase
Required genetic anomalies
BCR-ABL Ph+ (Philadelphia chromosome positive)
Required number of previous lines of therapy
1 2 3 or more
Required previous treatments
ATP pocket inhibitor Allosteric inhibitor
Excluded genetic anomalies
T315I TP53
Excluded previous treatments
Systemic Treatment-Naive
4 recruiting sites
Kartos Therapeutics
Phase 1 / Phase 2 Chronic myeloid leukemia (CML) #NCT04835584
Required disease stage
Chronic phase
Required genetic anomalies
BCR-ABL Ph+ (Philadelphia chromosome positive)
Required number of previous lines of therapy
1 2 3 or more
Required previous treatments
ATP pocket inhibitor Allosteric inhibitor
Excluded genetic anomalies
T315I TP53
Excluded previous treatments
Systemic Treatment-Naive
4 recruiting sites
Kartos Therapeutics
Phase 1 / Phase 2 Chronic myeloid leukemia (CML) #NCT06163430 #2023-507677-18-00
Required disease stage
Chronic phase
Required genetic anomalies
BCR-ABL
Required number of previous lines of therapy
1 2 3 or more
Required previous treatments
ATP pocket inhibitor Allosteric inhibitor
Excluded previous treatments
Systemic Treatment-Naive
6 recruiting sites
Terns, Inc.
Phase 1 Chronic myeloid leukemia (CML) #NCT05304377 #2023-503335-18-00
Required disease stage
Chronic phase
Required genetic anomalies
BCR-ABL
Required number of previous lines of therapy
1 2 3 or more
Required previous treatments
ATP pocket inhibitor Allosteric inhibitor
Excluded previous treatments
Systemic Treatment-Naive
5 recruiting sites
Enliven Therapeutics