Clinical trials for Brain tumors / Central nervous system tumors

68 currently recruiting clinical trials
Early Access Brain tumors / Central nervous system tumors
Required histologic types
Gliomas
Required histologic sub types
Astrocytoma grade II Oligodendroglioma grade II
Required genetic anomalies
IDH1/2
Required number of previous lines of therapy
None
Required previous treatments
Systemic Treatment-Naive Surgery
1 recruiting site
Servier
Phase 3 Brain tumors / Central nervous system tumors #NCT05902169 #2023-505829-14-00
Required histologic types
Gliomas
Required histologic sub types
Glioblastoma
Required number of previous lines of therapy
1
Required previous treatments
Surgery Immunotherapy Chemotherapy Radiotherapy
Excluded genetic anomalies
BRAF IDH1/2 NTRK-1/2/3
Excluded previous treatments
Systemic Treatment-Naive
3 recruiting sites
CarThera
Phase 3 Lymphoma Brain tumors / Central nervous system tumors #NCT07104032 #2025-523389-26-00
Required histologic types
B cell lymphoma Other primary CNS tumor
Required histologic sub types
Primary cerebral lymphoma Primary CNS lymphoma
Required number of previous lines of therapy
2 3 or more
Required previous treatments
Chemotherapy
Excluded previous treatments
Systemic Treatment-Naive Targeted therapy Other targeted therapy
2 recruiting sites
Ono Pharmaceutical Co. Ltd.
Phase 3 Brain tumors / Central nervous system tumors #NCT06809322 #2024-519404-27-00
Required histologic types
Gliomas
Required histologic sub types
Astrocytoma grade II Astrocytoma grade III
Required genetic anomalies
IDH1/2
Required number of previous lines of therapy
None
Required previous treatments
Surgery Radiochemotherapy
Excluded previous treatments
Systemic Treatment-Naive
5 recruiting sites
EORTC - Organisation Européenne pour la Recherche et le Traitement du Cancer
Phase 3 Brain tumors / Central nervous system tumors #NCT05512403 #2022-501688-42-00
Required histologic types
Gliomas
Required histologic sub types
Low-grade glioma
Required number of previous lines of therapy
None
Required previous treatments
Systemic Treatment-Naive
1 recruiting site
Hôpital central, Nancy, France
Phase 3 Brain tumors / Central nervous system tumors #NCT05904119
Required histologic types
Gliomas
Required histologic sub types
Glioblastoma
Required number of previous lines of therapy
1
Required previous treatments
Surgery Radiochemotherapy
Excluded genetic anomalies
IDH1/2
Excluded previous treatments
Systemic Treatment-Naive
10 recruiting sites
EORTC - Organisation Européenne pour la Recherche et le Traitement du Cancer
Phase 3 Brain tumors / Central nervous system tumors #NCT05476939 #2014-001929-32
Phase inclusion DIPG
Required histologic types
Gliomas
Required histologic sub types
Diffuse midline glioma grade IV
Required number of previous lines of therapy
None
Required previous treatments
Systemic Treatment-Naive
Excluded previous treatments
Chemotherapy Radiotherapy
33 recruiting sites
Gustave Roussy, Campus du cancer, Grand Paris
Phase 3 Brain tumors / Central nervous system tumors #NCT05476939 #2014-001929-32
Phase inclusion - gliomes diffus de la ligne médiane non-DIPG
Required histologic types
Gliomas
Required histologic sub types
Diffuse midline glioma grade IV
Required number of previous lines of therapy
None
Required previous treatments
Systemic Treatment-Naive
Excluded previous treatments
Chemotherapy Radiotherapy
34 recruiting sites
Gustave Roussy, Campus du cancer, Grand Paris
Phase 3 Brain tumors / Central nervous system tumors #NCT04702581
Required histologic types
Gliomas
Required histologic sub types
Oligodendroglioma grade II
Required genetic anomalies
IDH1/2
Required number of previous lines of therapy
None
Required previous treatments
Systemic Treatment-Naive Surgery
Excluded previous treatments
Chemotherapy Radiotherapy
14 recruiting sites
Hospices Civils de Lyon
Phase 2 Breast cancer Lung cancer Colon cancer Rectal cancer Anal cancer Kidney cancer Pancreas cancer Liver and bile duct cancer Bladder / Urinary Tract / Urethral cancer Stomach and esophageal cancer Endometrial cancer Ovarian / Fallopian tubes / Peritoneum cancer Head and neck cancer Sarcoma and GIST Thymus cancer Penile cancer and germ cell tumors Cervical / Vulvar / Vaginal cancer Small intestine and appendix cancer Thyroid and adrenal gland cancer Brain tumors / Central nervous system tumors Skin cancer #NCT07492680 #2025-524285-18-00
Required disease stage
Locally Advanced Metastatic
Required genetic anomalies
MTAP
Required number of previous lines of therapy
1 2 3 or more
Excluded previous treatments at advanced or metastatic stage
Systemic Treatment-Naive
1 recruiting site
Bristol-Myers Squibb